Biomarkers & Bioinformatics

Enabling Platform

Research Leaders:

befus 12-Gordon 12-McNagny
Dr. Dean Befus, Professor, Division of Pulmonary Medicine, Department of Medicine, University of Alberta; Astra-Zeneca Canada Inc., Chair in Asthma Research Dr. John Gordon, Professor, Division of Respirology, Critical Care & Sleep Medicine, Department of Medicine, University of Saskatchewan Dr. Kelly McNagny, Professor, Department of Medical Genetics, The University of British Columbia

Strategic Focus:

Biomarkers and Bioinformatics researchers focus on the discovery, development and commercialization of diagnostic tests and treatments for asthma and allergies, and manage, analyze and interpret data in order to accelerate advances in patient care, and personalized and public health.

Biomarkers and Bioinformatics Backgrounder
Biomarkers and Bioinformatics Publications




Cross-talk between Airway Epithelial and CD34 Hemopoietic Progenitor Cells Mediated by TSLP and IL-33 in Asthmatic and Normal Individuals

2008 - 2010

Delespesse, Guy

Develop and implement an allergen-gene environment database resource (Success Stories profile)

2007 - 2009

Daley, Denise

Development of an Adaptive Immune Phenotyping Monitoring Platform (Annual Report story: Discovering biomarkers of allergic disease)

2007 - 2009

Boulet, Louis-Philippe; Cyr, Michael; Keith, Paul; Kollmann, Tobias; Larché, Mark; O’Byrne, Paul; Ohayon, Jason; Sekaly, Rafick-Pierre; Turvey, Stuart; Waserman, Susan

Developmental plasticity and fetal programming of asthma in mice

2009 - 2012

Arck, Petra; Forsythe, Paul; Kobor, Michael; Petronis, Arturas; Pincus, Maike; Vliagoftis, Harissios; Wahn, Ulrich

Effects of probiotics on murine model of asthma (Success Stories profile)

2005 - 2006

Bienenstock, John; Forsythe, Paul

Environmental impact on the epithelial immune barrier in asthma (Success Stories profile)

2006 - 2008

Bai, Tony; Dorscheid, Del; Hegele, Richard; Knight, Darryl; van Eeden, Stephan

Environmental impact, inflammation and the role of IL-13 receptor a2

2009 - 2012

Agnes, George; Dorscheid, Del; Eades, Joshua; Gauvreau, Gail; Hegele, Richard; Inman, Mark; Mazer, Bruce; Pfeifer, Tom; Sandford, Andrew; Scott, James; Scott, Jeremy; Silverman, Frances

Functional TSLP genomics in vitro and ex vivo: human epithelial cell production of TSLP in relation to asthma development

2008 - 2010

Bosse, Yohan; Daley, Denise; Knight, Darryl; Laprise, Catherine; Paré, Peter; Sandford, Andrew

Further Development of the Genapha Website:An AllerGen Genomic database resource (Success Stories profile)

2010 - 2011

Daley, Denise

Genome-wide Association Results

2012 - 2014

Becker, Allan; Daley, Denise; Demanais, Florence; Kozyrskyj, Anita; Paré, Peter; Sandford, Andrew

Hemopoietic stem cell biomarkers in the diagnosis and prediction of allergic inflammation and disease (Success Stories profile)

2009 - 2012

Atkinson, Stephanie; Berthelet, Sharon; Deeley, Roger; Delespesse, Guy; Denburg, Judah; Djandji, Michel; Ellis, Anne; Gauvreau, Gail; Howard, Lisa; Larché, Mark; McCans, John; McNagny, Kelly; Murphy, Timothy; O’Byrne, Paul; Prescott, Susan; Storer, Andrew; Teo, Koon

Hemopoietic stem cell biomarkers in the diagnosis and prediction of allergic inflammation and disease: STEM (Stem cell Team for Emerging Markers)

2012 - 2016

Denburg, Judah; Ellis, Anne

Hemopoietic stem cells as biomarkers of atopy, airways inflammation, and sources of ‘epigenetic’ memory

2007 - 2009

Ackerman, Steven; Atkinson, Stephanie; Cyr, Michael; Denburg, Judah; Foster, Warren; Holt, Patrick; Prescott, Susan; Sly, Peter; Teo, Koon

Host environment interaction: Educating TLR-4+lymphocytes in childhood

2005 - 2006

Hamid, Qutayba; Martin, James; Mazer, Bruce

IDO, glutamate receptors and allergic inflammation

2005 - 2006

Duszyk, Marek; Ghahary, Aziz; Halayko, Andrew; Moqbel, Redwan

Intracellular Cytokine Production

2007 - 2009

Hamid, Qutayba; Mazer, Bruce


2009 - 2012

Adamko, Darryl; Becker, Allan; Custovic, Adnan; Ellis, Anne; Gauvreau, Gail; Mayers, Irvin; Moqbel, Redwan; Ratz, Jodan; Rowe, Brian; Sykes, Brian; Taylor, Neil; Vethanayagam, Dilini

Modulation of exocytosis in allergic inflammation

2005 - 2006

Dawny, Gregory; Eitzen, Gary; Lacy, Paige

Molecular interactions and ontologies for allergy and asthma (Annual Report story: Mapping molecular interactions of allergic disease)

2011 - 2013

Brinkman, Fiona

Neuroendocrine Regulation of Allergic Inflammation: Translational Studies (Success Stories profile)

2007 - 2009

Befus, Dean; Davison, Joe; Mathison, Ronald; Metwally, Essam; O’Byrne, Paul; Wilkinson, Mark

Neuroendocrine regulation of allergic reactions in animal models: Translation to humans

2007 - 2009

MacQueen, Glenda

Neuroimmune interactions: a partnership in drug development and translational research

2009 - 2012

Befus, Dean; Halloran, Philip; Hamid, Qutayba; Kollmann, Tobias; Mathison, Ronald; O’Byrne, Paul

Non-invasive diagnosis: Metabolics for the various phenotypes of asthma (formerly: Diagnosing the Various Phenotypes of Asthma: The Use of Urine NMR) (Success Stories profile)

2007 - 2009

Adamko, Darryl; Becker, Allan; Marrie, Tom; Mayers, Irvin; Moqbel, Redwan; Rowe, Brian; Sykes, Brian; Vethanayagam, Dilini

Perinatal stress and programming of allergic responses

2007 - 2009

Arck, Petra; Bienenstock, John; Forsythe, Paul; Heinrich, Joachim; Inman, Mark; Pincus, Maike; Wahn, Ulrich

Regulation of lung mucosal immune responses by heterologous exposure to multiple infectious and allergic agents

2006 - 2009

Brown, Earl; Coyle, Anthony; Gauldie, Jack; Hogaboam, Cory; Inman, Mark; Jordana, Manel; Stampfli, Martin; Xing, Zhou

Role of fibrocytes as biomarkers of airway remodelling in asthma: A proof of concept

2010 - 2012

Boulet, Louis-Philippe; Chakir, Jamila

Role of mast cells and eosinophils in allergic inflammationand fibrosis of the lung

2006 - 2009

Kelly, Margaret; Kubes, Paul; McNagny, Kelly; Mody, Chris

Study of the pathogenesis and reversibility of airway damage and repair during chronic mucosal immune responses to environmental allergies (Success Stories profile)

2006 - 2009

Hamid, Qutayba; Lavoie, Jean-Pierre; Lussier, Jacques; Martin, James

The distribution and function of FceR1 on nerves

2009 - 2012

Befus, Dean; Bienenstock, John; Forsythe, Paul; McNagny, Kelly; Rivera, Juan; Waserman, Susan

The link between upper and lower airway inflammation (Success Stories profile)

2005 - 2006

Boulet, Louis-Philippe; Denburg, Judah; Keith, Paul

Thymic Stromal Lymphopoitin-induced Cord Blood Hemopoietic Progenitors: Biomarkers for the Development of Atopy and Asthma

2008 - 2010

Denburg, Judah; Gauvreau, Gail; O’Byrne, Paul

TLR function in human neonates

2005 - 2006

Becker, Allan; HayGlass, Kent; Kozyrskyj, Anita; Marshall, Aaron; Morris, Maggie; Rola-Pleszczynski, Marek

Urine NMR-based Metabolomics for Asthma Diagnosis (Success Stories profile)

2012 - 2014

Adamko, Darryl; Busse, William; Gauvreau, Gail; Rowe, Brian; Sykes, Brian; Vliagoftis, Harissios

Urine NMR-Metabolomics for Asthma Diagnosis: Respirlyte (Patent) (Success Stories profile)

2013 - 2014

Adamko, Darryl

Vaccines for asthma & allergies – a bacterial immune-prophylactic and therapeutic approach (Success Stories profile)

2009 - 2012

Gordon, John; Kollmann, Tobias; Larché, Mark; Mazer, Bruce; McNagny, Kelly

A network biology approach to allergy requires annotated database of molecular interaction (Success Stories profile)

2012 - 2014

Brinkman, Fiona; Lynn, David

Allergic Asthma functional & Pharmaco-genomics for Early and Late Phase Response Biomarkers

2012 - 2014

Gauvreau, Gail; McManus, Bruce; Tebbutt, Scott

Antenatal steroid therapy for fetal lung maturation: Is there an association with childhood asthma (Success Stories profile)

2005 - 2006

Beyene, Joseph; Mustard, Cameron; To, Teresa

Biomarkers of a Sympathetic Anti-inflammatory Pathway, Neuro-regulation of Sympathetic Anti-inflammatory Activity

2012 - 2014

Befus, Dean; Boulet, Louis-Philippe; Davies, Kelvin Paul; Gauvreau, Gail; O’Byrne, Paul; Ritz, Thomas

Blocking Human CD34 Expression as a Therapeutic for Mucosal Inflammatory Disease

2009 - 2011

McNagny, Kelly

CD34 as a therapeutic target for allergic inflammation and asthma (Success Stories peofile)

2012 - 2014

Blanchet, Marie-Renee; McNagny, Kelly

Clustering approaches to unravel complex asthma phenotypes

2010 - 2012

Becker, Allan; Daley, Denise; James, Alan; Kozyrskyj, Anita; Laprise, Catherine

Commercialization of a Metabolomic-Based Diagnostic for Asthma

2011 - 2012

Adamko, Darryl; Taylor, Neil; Yatscoff, Randy