Enabling Platform
Research Leaders:
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| Dr. Dean Befus, Professor, Division of Pulmonary Medicine, Department of Medicine, University of Alberta; Astra-Zeneca Canada Inc., Chair in Asthma Research | Dr. John Gordon, Professor, Division of Respirology, Critical Care & Sleep Medicine, Department of Medicine, University of Saskatchewan | Dr. Kelly McNagny, Professor, Department of Medical Genetics, The University of British Columbia |
Strategic Focus:
Biomarkers and Bioinformatics researchers focus on the discovery, development and commercialization of diagnostic tests and treatments for asthma and allergies, and manage, analyze and interpret data in order to accelerate advances in patient care, and personalized and public health.
Biomarkers and Bioinformatics Backgrounder
Biomarkers and Bioinformatics Publications
Projects:
| Project | Term | Investigators |
|---|---|---|
|
Cross-talk between Airway Epithelial and CD34 Hemopoietic Progenitor Cells Mediated by TSLP and IL-33 in Asthmatic and Normal Individuals |
2008 - 2010 |
Delespesse, Guy |
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Develop and implement an allergen-gene environment database resource (Success Stories profile) |
2007 - 2009 |
Daley, Denise |
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Development of an Adaptive Immune Phenotyping Monitoring Platform (Annual Report story: Discovering biomarkers of allergic disease) |
2007 - 2009 |
Boulet, Louis-Philippe; Cyr, Michael; Keith, Paul; Kollmann, Tobias; Larché, Mark; O’Byrne, Paul; Ohayon, Jason; Sekaly, Rafick-Pierre; Turvey, Stuart; Waserman, Susan |
|
Developmental plasticity and fetal programming of asthma in mice |
2009 - 2012 |
Arck, Petra; Forsythe, Paul; Kobor, Michael; Petronis, Arturas; Pincus, Maike; Vliagoftis, Harissios; Wahn, Ulrich |
|
Effects of probiotics on murine model of asthma (Success Stories profile) |
2005 - 2006 |
Bienenstock, John; Forsythe, Paul |
|
Environmental impact on the epithelial immune barrier in asthma (Success Stories profile) |
2006 - 2008 |
Bai, Tony; Dorscheid, Del; Hegele, Richard; Knight, Darryl; van Eeden, Stephan |
|
Environmental impact, inflammation and the role of IL-13 receptor a2 |
2009 - 2012 |
Agnes, George; Dorscheid, Del; Eades, Joshua; Gauvreau, Gail; Hegele, Richard; Inman, Mark; Mazer, Bruce; Pfeifer, Tom; Sandford, Andrew; Scott, James; Scott, Jeremy; Silverman, Frances |
|
Functional TSLP genomics in vitro and ex vivo: human epithelial cell production of TSLP in relation to asthma development |
2008 - 2010 |
Bosse, Yohan; Daley, Denise; Knight, Darryl; Laprise, Catherine; Paré, Peter; Sandford, Andrew |
|
Further Development of the Genapha Website:An AllerGen Genomic database resource (Success Stories profile) |
2010 - 2011 |
Daley, Denise |
|
Genome-wide Association Results |
2012 - 2014 |
Becker, Allan; Daley, Denise; Demanais, Florence; Kozyrskyj, Anita; Paré, Peter; Sandford, Andrew |
|
Hemopoietic stem cell biomarkers in the diagnosis and prediction of allergic inflammation and disease (Success Stories profile) |
2009 - 2012 |
Atkinson, Stephanie; Berthelet, Sharon; Deeley, Roger; Delespesse, Guy; Denburg, Judah; Djandji, Michel; Ellis, Anne; Gauvreau, Gail; Howard, Lisa; Larché, Mark; McCans, John; McNagny, Kelly; Murphy, Timothy; O’Byrne, Paul; Prescott, Susan; Storer, Andrew; Teo, Koon |
|
Hemopoietic stem cell biomarkers in the diagnosis and prediction of allergic inflammation and disease: STEM (Stem cell Team for Emerging Markers) |
2012 - 2016 |
Denburg, Judah; Ellis, Anne |
|
Hemopoietic stem cells as biomarkers of atopy, airways inflammation, and sources of ‘epigenetic’ memory |
2007 - 2009 |
Ackerman, Steven; Atkinson, Stephanie; Cyr, Michael; Denburg, Judah; Foster, Warren; Holt, Patrick; Prescott, Susan; Sly, Peter; Teo, Koon |
|
Host environment interaction: Educating TLR-4+lymphocytes in childhood |
2005 - 2006 |
Hamid, Qutayba; Martin, James; Mazer, Bruce |
|
IDO, glutamate receptors and allergic inflammation |
2005 - 2006 |
Duszyk, Marek; Ghahary, Aziz; Halayko, Andrew; Moqbel, Redwan |
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Intracellular Cytokine Production |
2007 - 2009 |
Hamid, Qutayba; Mazer, Bruce |
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Metabolomics |
2009 - 2012 |
Adamko, Darryl; Becker, Allan; Custovic, Adnan; Ellis, Anne; Gauvreau, Gail; Mayers, Irvin; Moqbel, Redwan; Ratz, Jodan; Rowe, Brian; Sykes, Brian; Taylor, Neil; Vethanayagam, Dilini |
|
Modulation of exocytosis in allergic inflammation |
2005 - 2006 |
Dawny, Gregory; Eitzen, Gary; Lacy, Paige |
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Molecular interactions and ontologies for allergy and asthma (Annual Report story: Mapping molecular interactions of allergic disease) |
2011 - 2013 |
Brinkman, Fiona |
|
Neuroendocrine Regulation of Allergic Inflammation: Translational Studies (Success Stories profile) |
2007 - 2009 |
Befus, Dean; Davison, Joe; Mathison, Ronald; Metwally, Essam; O’Byrne, Paul; Wilkinson, Mark |
|
Neuroendocrine regulation of allergic reactions in animal models: Translation to humans |
2007 - 2009 |
MacQueen, Glenda |
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Neuroimmune interactions: a partnership in drug development and translational research |
2009 - 2012 |
Befus, Dean; Halloran, Philip; Hamid, Qutayba; Kollmann, Tobias; Mathison, Ronald; O’Byrne, Paul |
|
Non-invasive diagnosis: Metabolics for the various phenotypes of asthma (formerly: Diagnosing the Various Phenotypes of Asthma: The Use of Urine NMR) (Success Stories profile) |
2007 - 2009 |
Adamko, Darryl; Becker, Allan; Marrie, Tom; Mayers, Irvin; Moqbel, Redwan; Rowe, Brian; Sykes, Brian; Vethanayagam, Dilini |
|
Perinatal stress and programming of allergic responses |
2007 - 2009 |
Arck, Petra; Bienenstock, John; Forsythe, Paul; Heinrich, Joachim; Inman, Mark; Pincus, Maike; Wahn, Ulrich |
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Regulation of lung mucosal immune responses by heterologous exposure to multiple infectious and allergic agents |
2006 - 2009 |
Brown, Earl; Coyle, Anthony; Gauldie, Jack; Hogaboam, Cory; Inman, Mark; Jordana, Manel; Stampfli, Martin; Xing, Zhou |
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Role of fibrocytes as biomarkers of airway remodelling in asthma: A proof of concept |
2010 - 2012 |
Boulet, Louis-Philippe; Chakir, Jamila |
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Role of mast cells and eosinophils in allergic inflammationand fibrosis of the lung |
2006 - 2009 |
Kelly, Margaret; Kubes, Paul; McNagny, Kelly; Mody, Chris |
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Study of the pathogenesis and reversibility of airway damage and repair during chronic mucosal immune responses to environmental allergies (Success Stories profile) |
2006 - 2009 |
Hamid, Qutayba; Lavoie, Jean-Pierre; Lussier, Jacques; Martin, James |
|
The distribution and function of FceR1 on nerves |
2009 - 2012 |
Befus, Dean; Bienenstock, John; Forsythe, Paul; McNagny, Kelly; Rivera, Juan; Waserman, Susan |
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The link between upper and lower airway inflammation (Success Stories profile) |
2005 - 2006 |
Boulet, Louis-Philippe; Denburg, Judah; Keith, Paul |
|
Thymic Stromal Lymphopoitin-induced Cord Blood Hemopoietic Progenitors: Biomarkers for the Development of Atopy and Asthma |
2008 - 2010 |
Denburg, Judah; Gauvreau, Gail; O’Byrne, Paul |
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TLR function in human neonates |
2005 - 2006 |
Becker, Allan; HayGlass, Kent; Kozyrskyj, Anita; Marshall, Aaron; Morris, Maggie; Rola-Pleszczynski, Marek |
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Urine NMR-based Metabolomics for Asthma Diagnosis (Success Stories profile) |
2012 - 2014 |
Adamko, Darryl; Busse, William; Gauvreau, Gail; Rowe, Brian; Sykes, Brian; Vliagoftis, Harissios |
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Urine NMR-Metabolomics for Asthma Diagnosis: Respirlyte (Patent) (Success Stories profile) |
2013 - 2014 |
Adamko, Darryl |
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Vaccines for asthma & allergies – a bacterial immune-prophylactic and therapeutic approach (Success Stories profile) |
2009 - 2012 |
Gordon, John; Kollmann, Tobias; Larché, Mark; Mazer, Bruce; McNagny, Kelly |
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A network biology approach to allergy requires annotated database of molecular interaction (Success Stories profile) |
2012 - 2014 |
Brinkman, Fiona; Lynn, David |
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Allergic Asthma functional & Pharmaco-genomics for Early and Late Phase Response Biomarkers |
2012 - 2014 |
Gauvreau, Gail; McManus, Bruce; Tebbutt, Scott |
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Antenatal steroid therapy for fetal lung maturation: Is there an association with childhood asthma (Success Stories profile) |
2005 - 2006 |
Beyene, Joseph; Mustard, Cameron; To, Teresa |
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Biomarkers of a Sympathetic Anti-inflammatory Pathway, Neuro-regulation of Sympathetic Anti-inflammatory Activity |
2012 - 2014 |
Befus, Dean; Boulet, Louis-Philippe; Davies, Kelvin Paul; Gauvreau, Gail; O’Byrne, Paul; Ritz, Thomas |
|
Blocking Human CD34 Expression as a Therapeutic for Mucosal Inflammatory Disease |
2009 - 2011 |
McNagny, Kelly |
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CD34 as a therapeutic target for allergic inflammation and asthma (Success Stories peofile) |
2012 - 2014 |
Blanchet, Marie-Renee; McNagny, Kelly |
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Clustering approaches to unravel complex asthma phenotypes |
2010 - 2012 |
Becker, Allan; Daley, Denise; James, Alan; Kozyrskyj, Anita; Laprise, Catherine |
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Commercialization of a Metabolomic-Based Diagnostic for Asthma |
2011 - 2012 |
Adamko, Darryl; Taylor, Neil; Yatscoff, Randy |