Enabling Platform
Research Leaders:
 |
 |
| Dr. Jeffrey Brook, Senior Scientist, Air Quality Research Branch, Environment Canada; Assistant Professor, Division of Occupational & Environmental Health, Dalla Lana School of Public Health, University of Toronto | Dr. Michael Kobor, Professor and Canada Research Chair in Social Epigenetics, Department of Medical Genetics, The University of British Columbia |
Strategic Focus:
Gene-Environment Interactions focuses on genetic, environmental and epigenetic research that aims to discover novel therapies and diagnostics, and facilitate the development of novel public health interventions and policies in the areas of asthma and allergies.
Gene-Environment Interactions Backgrounder
Gene-Environment Interactions Publications
Projects:
| Project | Term | Investigators |
|---|---|---|
|
Allergic asthma: Air pollution and allergen interactions |
2005 - 2006 |
Brook, Jeff; Corey, Paul; Denburg, Judah; Palaniyar, Nades; Silverman, Frances; Tarlo, Susan; van Eeden, Stephan |
|
Allergy-Brain Connection (ABC) Research Team |
2012 - 2016 |
Becker, Allan; Brownell, Marni; Campbell, Tavis; Chartier, Mariette; Field, Catherine; Giesbrecht, Gerry; Kaplan, Bonnie; Kozyrskyj, Anita; Letourneau, Nicole; Mandhane, Piush; Tough, Suzanne; Wynne-Edwards, Katherine |
|
Development of a Human Phthalate Inhalation Exposure Model |
2008 - 2010 |
Agnes, George; Allen, Ryan; Carlsten, Chris; Takaro, Timothy; van Eeden, Stephan |
|
Development of sensor arrays for the assessment of exposure to air pollutants |
2011 - 2013 |
Evans, Greg |
|
Environmental Affects on Allergic Airway Disease |
2007 - 2009 |
Alexis, Neil; Brook, Jeff; McNagny, Kelly; Ritz, Stacey; Scott, Jeremy; Silverman, Frances; Zamel, Noe |
|
Functional genetics in allergy |
2009 - 2012 |
Becker, Allan; Cameron, Lisa; Daley, Denise; Kollmann, Tobias; Laprise, Catherine; Larche, Mark; Sandford, Andrew; Tebbutt, Scott; Turvey, Stuart |
|
Genetics of the early and late responses to AllerGen challenge (Annual Report story: Two NCEs team up to develop tests for allergic asthma) |
2009 - 2012 |
Borchers, Christoph; Boulet, Louis-Philippe; Carlsten, Chris; Cockcroft, Don; Ellis, Anne; FitzGerald, Mark; Gauvreau, Gail; Mayers, Irvin; O’Byrne, Paul; Radzioch, Danuta; Ratz, Jodan; Tebbutt, Scott |
|
Genome wide association study of allergy and asthma in the Canadian Asthma Primary Prevention Study (CAPPS) and the Study of Allergy Genes and Environment (SAGE) |
2009 - 2012 |
Becker, Allan; Carlsten, Chris; Chan-Yeung, Moira; Daley, Denise; Kozyrskyj, Anita; Laprise, Catherine; Paré, Peter; Sandford, Andrew |
|
Maternal distress and the development of atopic disease in children: Potential pathways and interventions |
2009 - 2011 |
Becker, Allan; Brownell, Marni; Chartier, Mariette; Kozyrskyj, Anita; Letourneau, Nicole; Mandhane, Piush |
|
Maternal Stress and Childhood Asthma (Success Stories profile) |
2005 - 2006 |
Becker, Allan; HayGlass, Kent; Kozyrskyj, Anita; MacNeil, Brian |
|
Method for measuring phthalate concentrations representative of exposure (Success Stories profile) |
2011 - 2013 |
Diamond, Miriam |
|
Pan-Canadian study of gene-environment interactions in the etiology of occupational asthma |
2007 - 2009 |
Beach, Jeremy; Burstyn, Igor; Cherry, Nicola |
|
Postpartum Distress and Childhood Asthma: The Genetics, and the Social and Ethical Impacts of this Genetic Association |
2007 - 2009 |
Austin, Jehannine; Becker, Allan; Daley, Denise; Kozyrskyj, Anita; Letourneau, Nicole; Sherwin, Susan |
|
Rapid Environmental Effects on Genes: The Lens of Epigenetics (REEGLE) (Success Stories profile; Annual Report story: Pan-Canadian team explores the epigenetics of allergic disease) |
2012 - 2016 |
Baccarelli, Andrea; Brauer, Michael; Brook, Jeff; Carlsten, Chris; Ellis, Anne; Kobor, Michael; Kollmann, Tobias; Miller, Greg; Silverman, Frances; Takaro, Timothy; Turvey, Stuart; Scherer, Stephen; Yuen, Ryan |
|
Respiratory syncytial virus in the development of infant wheezing disorders: a bench to bedside approach to gene-virus interactions |
2009 - 2012 |
Daley, Denise; Hegele, Richard; McKerlie, Colin; Moraes, Theo; Richardson, Susan; Sandford, Andrew; Subbarao, Padmaja; Tang, Patrick; Turvey, Stuart |
|
Strengthening the Case for Ongoing Reduction of Exposure to Traffic-Related Air Pollution (SCORE-TRAP) |
2012 - 2016 |
Baccarelli, Andrea; Brauer, Michael; Brook, Jeff; Carlsten, Chris; Ellis, Anne; Gauvreau, Gail; Silverman, Frances; Tebbutt, Scott |
|
Stress, asthma and atopy socio-spatial investigations (SAASSI) |
2007 - 2009 |
Becker, Allan; Elliott, Susan; HayGlass, Kent; Kozyrskyj, Anita; Letourneau, Nicole; MacNeil, Brian; Mignone, Javier |
|
The Canadian Asthma Primary Prevention Study: home environment at the 14-year assessment |
2010 - 2012 |
Becker, Allan; Chan-Yeung, Moira; Sevenhuysen, Gustaaf; Tittlemier, Sheryl; Wong, Charles |
|
Traffic-related air pollution as a risk factor for the development of childhood asthma (Success Stories profile; project website) |
2009 - 2012 |
Allen, Ryan; Becker, Allan; Brauer, Michael; Brook, Jeff; Brunekreef, Bert; Carlsten, Chris; Chan-Yeung, Moira; Heinrich, Joachim; Henderson, John; Kerkhof, Marjan; Koppelman, Gerard; Kozyrskyj, Anita; Pershagen, Goran |
|
Validation of genetic associations in asthma and allergy in Canadian families (Success Stories profile) |
2005 - 2006 |
Beilby, John; Hudson, Thomas; James, Alan; Kaplan, Feige; Kozyrskyj, Anita; Laprise, Catherine; Musk, Bill; Palmer, Lyle; Paré, Peter; Sandford, Andrew |
|
An Integrative Multidimensional Genomic and Epigenomic Approach for the Study of Short-Term Diesel Exhaust on Asthmatics (Success Stories profile) |
2010 - 2012 |
Brook, Jeff; Carlsten, Chris; Kobor, Michael; Lam, Wan; Scott, Jeremy; Silverman, Frances; Tebbutt, Scott |
|
Better Exposure Avoidance Measures (BEAM) and New Environmental Sensor Tool Development (Success Stories profile) |
2012 - 2016 |
Allen, Ryan; Brauer, Michael; Brook, Jeff; Diamond, Miriam; Evans, Greg; Jiping, Zu; Scott, James; Silverman, Frances; Takaro, Timothy; Wheeler, Amanda; Arrandale, Victoria; Bassil, Kate; Chapman, Alex; Gibson, Mark; Jantunen, Liisa; Sbihi, Hind; Setton, Eleanor; Sodhi, Rana |
|
Cardiopulmonary consequences of air pollution in a murine model of allergic asthma (Profile in reAction) |
2005 - 2006 |
Brook, Jeff; Liu, Ling; Marsden, Philip; Mehta, Sanjay; Palaniyar, Nades; Rajagopalan, Sanjay; Ritz, Stacey; Scott, Jeremy; Silverman, Frances; Suntres, Zacharias; Vijay, Hari; Ward, Mike |