Gene-Environment Interactions

Enabling Platform

Research Leaders:

Jeff Brook 2013 MKobor-2
Dr. Jeffrey Brook, Senior Scientist, Air Quality Research Branch, Environment Canada; Assistant Professor, Division of Occupational & Environmental Health, Dalla Lana School of Public Health, University of Toronto Dr. Michael Kobor, Professor and Canada Research Chair in Social Epigenetics, Department of Medical Genetics, The University of British Columbia

Strategic Focus:

Gene-Environment Interactions focuses on genetic, environmental and epigenetic research that aims to discover novel therapies and diagnostics, and facilitate the development of novel public health interventions and policies in the areas of asthma and allergies.

Gene-Environment Interactions Backgrounder
Gene-Environment Interactions Publications




Allergic asthma: Air pollution and allergen interactions

2005 - 2006

Brook, Jeff; Corey, Paul; Denburg, Judah; Palaniyar, Nades; Silverman, Frances; Tarlo, Susan; van Eeden, Stephan

Allergy-Brain Connection (ABC) Research Team

2012 - 2016

Becker, Allan; Brownell, Marni; Campbell, Tavis; Chartier, Mariette; Field, Catherine; Giesbrecht, Gerry; Kaplan, Bonnie; Kozyrskyj, Anita; Letourneau, Nicole; Mandhane, Piush; Tough, Suzanne; Wynne-Edwards, Katherine

Development of a Human Phthalate Inhalation Exposure Model

2008 - 2010

Agnes, George; Allen, Ryan; Carlsten, Chris; Takaro, Timothy; van Eeden, Stephan

Development of sensor arrays for the assessment of exposure to air pollutants

2011 - 2013

Evans, Greg

Environmental Affects on Allergic Airway Disease

2007 - 2009

Alexis, Neil; Brook, Jeff; McNagny, Kelly; Ritz, Stacey; Scott, Jeremy; Silverman, Frances; Zamel, Noe

Functional genetics in allergy

2009 - 2012

Becker, Allan; Cameron, Lisa; Daley, Denise; Kollmann, Tobias; Laprise, Catherine; Larche, Mark; Sandford, Andrew; Tebbutt, Scott; Turvey, Stuart

Genetics of the early and late responses to AllerGen challenge (Annual Report story: Two NCEs team up to develop tests for allergic asthma)

2009 - 2012

Borchers, Christoph; Boulet, Louis-Philippe; Carlsten, Chris; Cockcroft, Don; Ellis, Anne; FitzGerald, Mark; Gauvreau, Gail; Mayers, Irvin; O’Byrne, Paul; Radzioch, Danuta; Ratz, Jodan; Tebbutt, Scott

Genome wide association study of allergy and asthma in the Canadian Asthma Primary Prevention Study (CAPPS) and the Study of Allergy Genes and Environment (SAGE)

2009 - 2012

Becker, Allan; Carlsten, Chris; Chan-Yeung, Moira; Daley, Denise; Kozyrskyj, Anita; Laprise, Catherine; Paré, Peter; Sandford, Andrew

Maternal distress and the development of atopic disease in children: Potential pathways and interventions

2009 - 2011

Becker, Allan; Brownell, Marni; Chartier, Mariette; Kozyrskyj, Anita; Letourneau, Nicole; Mandhane, Piush

Maternal Stress and Childhood Asthma (Success Stories profile)

2005 - 2006

Becker, Allan; HayGlass, Kent; Kozyrskyj, Anita; MacNeil, Brian

Method for measuring phthalate concentrations representative of exposure (Success Stories profile)

2011 - 2013

Diamond, Miriam

Pan-Canadian study of gene-environment interactions in the etiology of occupational asthma

2007 - 2009

Beach, Jeremy; Burstyn, Igor; Cherry, Nicola

Postpartum Distress and Childhood Asthma: The Genetics, and the Social and Ethical Impacts of this Genetic Association

2007 - 2009

Austin, Jehannine; Becker, Allan; Daley, Denise; Kozyrskyj, Anita; Letourneau, Nicole; Sherwin, Susan

Rapid Environmental Effects on Genes: The Lens of Epigenetics (REEGLE) (Success Stories profile; Annual Report story: Pan-Canadian team explores the epigenetics of allergic disease)

2012 - 2016

Baccarelli, Andrea; Brauer, Michael; Brook, Jeff; Carlsten, Chris; Ellis, Anne; Kobor, Michael; Kollmann, Tobias; Miller, Greg; Silverman, Frances; Takaro, Timothy; Turvey, Stuart; Scherer, Stephen; Yuen, Ryan

Respiratory syncytial virus in the development of infant wheezing disorders: a bench to bedside approach to gene-virus interactions

2009 - 2012

Daley, Denise; Hegele, Richard; McKerlie, Colin; Moraes, Theo; Richardson, Susan; Sandford, Andrew; Subbarao, Padmaja; Tang, Patrick; Turvey, Stuart

Strengthening the Case for Ongoing Reduction of Exposure to Traffic-Related Air Pollution (SCORE-TRAP)

2012 - 2016

Baccarelli, Andrea; Brauer, Michael; Brook, Jeff; Carlsten, Chris; Ellis, Anne; Gauvreau, Gail; Silverman, Frances; Tebbutt, Scott

Stress, asthma and atopy socio-spatial investigations (SAASSI)

2007 - 2009

Becker, Allan; Elliott, Susan; HayGlass, Kent; Kozyrskyj, Anita; Letourneau, Nicole; MacNeil, Brian; Mignone, Javier

The Canadian Asthma Primary Prevention Study: home environment at the 14-year assessment

2010 - 2012

Becker, Allan; Chan-Yeung, Moira; Sevenhuysen, Gustaaf; Tittlemier, Sheryl; Wong, Charles

Traffic-related air pollution as a risk factor for the development of childhood asthma (Success Stories profile; project website)

2009 - 2012

Allen, Ryan; Becker, Allan; Brauer, Michael; Brook, Jeff; Brunekreef, Bert; Carlsten, Chris; Chan-Yeung, Moira; Heinrich, Joachim; Henderson, John; Kerkhof, Marjan; Koppelman, Gerard; Kozyrskyj, Anita; Pershagen, Goran

Validation of genetic associations in asthma and allergy in Canadian families (Success Stories profile)

2005 - 2006

Beilby, John; Hudson, Thomas; James, Alan; Kaplan, Feige; Kozyrskyj, Anita; Laprise, Catherine; Musk, Bill; Palmer, Lyle; Paré, Peter; Sandford, Andrew

An Integrative Multidimensional Genomic and Epigenomic Approach for the Study of Short-Term Diesel Exhaust on Asthmatics (Success Stories profile)

2010 - 2012

Brook, Jeff; Carlsten, Chris; Kobor, Michael; Lam, Wan; Scott, Jeremy; Silverman, Frances; Tebbutt, Scott

Better Exposure Avoidance Measures (BEAM) and New Environmental Sensor Tool Development (Success Stories profile)

2012 - 2016

Allen, Ryan; Brauer, Michael; Brook, Jeff; Diamond, Miriam; Evans, Greg; Jiping, Zu; Scott, James; Silverman, Frances; Takaro, Timothy; Wheeler, Amanda; Arrandale, Victoria; Bassil, Kate; Chapman, Alex; Gibson, Mark; Jantunen, Liisa; Sbihi, Hind; Setton, Eleanor; Sodhi, Rana

Cardiopulmonary consequences of air pollution in a murine model of allergic asthma (Profile in reAction)

2005 - 2006

Brook, Jeff; Liu, Ling; Marsden, Philip; Mehta, Sanjay; Palaniyar, Nades; Rajagopalan, Sanjay; Ritz, Stacey; Scott, Jeremy; Silverman, Frances; Suntres, Zacharias; Vijay, Hari; Ward, Mike